Mlkl^m3Btlr

ENU-induced G to C transversion at base pair 111,319,716 (v38) on chromosome 8, or base pair 18,741 in the GenBank genomic region NC_000074. The mutation is within the splice donor site of intron 6, one base pair away from exon 6 (out of 11 total exons). The effect of the mutation on the mRNA sequence and mutant protein expression is unknown. In the event of exon 6 skipping, the aberrant transcript would have a deletion of the 136 base pair exon 6 (corresponding to amino acids 263-308), a frame-shift, and coding of 29 aberrant amino acids followed by a premature stop codon (within exon 8) after amino acid 291. (J:234251)