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The full-length human cDNA with a T to G mutation at nucleotide 2573 resulting in the substitution of arginine for leucine at codon 858 and also tagged at the COOH-terminal end with FLAG is under the control of the human type II alveolar epithelial cell specific surfactant protein-C promoter. RT-PCR from hemizygous mice shows an approximate 1.5- to 3-fold greater expression of the transgene compared with endogenous Egfr. Western blot confirmed restricted expression to lung tissue. (J:152157)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
