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The open reading frame was replaced with a frt-flanked neo cassette and loxP sites flanking the open reading frame in exon 7. The floxed exon 7 region was removed via cre-mediated recombination and the neo cassette via flp-mediated recombination. Lack of the open reading frame was confirmed by RT-PCR, however RT-PCR of the 3-UTR (without the ORF) exhibits an approximate 1.5-fold increase in transcript levels. (J:228903)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
