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Cre recombinase-induced recombination between a loxP site at the App locus (Apptm1Yah) and a loxP site in Runx1 (Runx1tm1Yg) on the oposite Chr 16 homolog (in trans) resulted in duplication of the intervening chromosomal segment. To achieve this, a male mouse carrying Runx1tm1Yg was mated to a female bearing Hprttm1(CAG-cre)Mnn, and a female offspring with both targeted alleles was bred with a male carrying Apptm1Yah. A daughter carrying all three modifications, in whose oocytes recombination occurred, was mated to C57BL/6 males to obtain offspring with the duplication. (J:82809)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
