Log In|Sign Up
EN
The transgene contains a single copy of the mouse tyrosinase gene including all five exons, the 5' and 3' untranslated regions (UTRs), and ~155 kb of upstream sequence from which the locus control region (LCR), at -12 kb, has been deleted, leaving the upstream sequence intact. Transgenic mice were generated by IMYT (ICSI-mediated YAC transfer) of the 250-kb yeast artificial chromosome (YAC) YRTdeltaLCR, derived by homologous recombination of the YAC YRT2; YRT2 originated from a YAC library made from strain C3H genomic DNA. Expression of the transgene is demonstrated by its partial rescue of the pigment phenotype of albino mice. (J:211464)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
