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The transgene contains a single copy of the mouse tyrosinase gene, including all five exons, the 5' and 3' untranslated regions (UTRs), and ~155 kb of upstream sequence encompassing the locus control region (LCR) regulatory elements at -12 kb, of which the box A element has been deleted. Transgenic mice were produced by pronuclear injection of mouse oocytes with the 250-kb yeast artificial chromosome (YAC) YRT2deltaA, derived by homologous recombination of the YAC YRT2; YRT2 originated from a YAC library made from strain C3H genomic DNA. Expression of the transgene is demonstrated by its partial rescue of the pigment phenotype of albino NMRI mice. (J:211470)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
