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The transgene contains a single copy of the entire mouse tyrosinase expression domain, including all five exons, the 5' and 3' untranslated regions (UTRs), and ~155 kb of 5' upstream sequences encompassing the locus control region (LCR) regulatory elements at -12 kb. Transgenic mice were generated by pronuclear injection of mouse oocytes with a 250-kb yeast artificial chromosome (YAC), YRT2, from a YAC library generated from strain C3H genomic DNA. Expression of the transgene is demonstrated by its complete rescue of the pigment phenotype of albino NMRI mice. (J:4498)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
