The construct inserted a three-frame triple stop codon cassette immediately downstream of the first codon in the exon 8 (ATG TAA A TAG A TGA), causing premature translation termination. A kanamycin-neomycin resistance gene cassette was inserted downstream of the stop codons. (J:229314)
Basic Information
(C57BL/6 x 129P2/OlaHsd)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count