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An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted in exon 2 downstream of the coding sequence. Cre-mediated recombination removed the loxP-flanked region, including the coding sequence and the selection cassette. RT-PCR analysis revealed absence of RNA expression in the liver, whole brain, and skeletal muscle of homozygous mutant mice. Absence of serum levels in chow-fed conditions was confirmed by ELISA. (J:225402)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
