The targeting construct introduced into the locus a CAG promoter, loxP site, neomycin resistance cassette, loxP2272 site, the coding sequence with an IRES and Venus reporter cassette, loxP site and loxP2272 site. Cre-mediated recombination removed the selection cassette and allowed for expression of the inserted sequences. (J:224861)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count