Jarid2^{tm1c(KOMP)Wtsi}

The L1L2_gt0 cassette was inserted at position 44976315 of Chromosome 13 upstream of the critical exon 2 (Build GRCm39; exon 3 in transcript ENSMUST00000044608). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 2 (exon 3 in transcript ENSMUST00000044608) at position 44977253. The critical exon 2 (exon 3 in transcript ENSMUST00000044608) is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:232066)