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The targeting construct introduced several nucleotide substitutions (N46A [AAT to GCT] and Y50A [TAC to GCC] in exon 2 and N122A [AAC to GCC] and Y126A [TAT to GCT] in exon 3), that results in the amino acid substitutions of alanine for asparagine and tyrosine at positions 122 and 126 (N122A/Y126A). The final allele lacks a self-deleting neomycin resistance cassette. (J:252669)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
