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A single CRISPR guide RNA was designed to target the coding sequence of exon 2 before the transmembrane region. This allele was generated by injecting the guide RNA and Cas9 mRNA into the pronucleus and cytoplasm and an allele containing a 2-bp insertion (GT into exon 2) that disrupts the ORF after codon 16 was chosen. This mutation is expected to produce a truncated protein lacking the transmembrane domain. (J:229305)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
