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EN
The targeting construct replaced 20 kb of endogenous sequence from 5' end of exon 2 to the 5' end of exon 7 with a STOP cassette, IRES, beta-geo and polyadenylation sequence. RNA blotting confirmed the absence of transcript expression in intestinal epithelial cells. Immunohistochemistry confirmed the absence of protein expression in the small intestine and colon. (J:224768, J:231808)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
