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Exon 3 was replaced with a modified one in which two point mutations result in the amino acid substitution of a serine for selenocysteine at position 46 (U46S). A floxed neomycin resistance cassette was inserted downstream of exon 7. Immunoblot analysis revealed a significant up-regulation of Gpx4 protein levels in all somatic tissues of heterozygous mutant mice; however, significantly decreased levels of Gpx4-specific activities were detectable only in heterozygous livers, whereas no difference was seen in kidney, brain and heart. (J:225651)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
