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Using two sgRNAs and CRISPR/Cas9 technology (with D10A mutatnt of Cas9), 22 nucleotides (GTCAAAGGTTCAGGATGATTTT in NM_054066) were deleted from exon 3. Immunoblots with sperm derived protein confirmed the lack of full-length peptided expressed from this allele. Any potential C-terminally truncated peptide expressed from this allele would lack all functional domains. (J:243414)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
