A loxP site was inserted upstream of exon 21. A floxed neomycin resistance cassette was inserted downstream of exon 21. Cre-mediated recombination removed the selection cassette and left exon 21 floxed. (J:227240)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count