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Exon 7 was modified to contain two nucleotide changes (CT to GG) that result in the amino acid substitution of alanine for glutamic acid at position 260 (E260A). A C-terminal hemagglutinin (HA) epitope tag (YPYDVPDY) was inserted. The IRES, MAPT (tau) and GFP reporter fusion was inserted into the 3' UTR. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the reporter fusion. (J:229180)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
