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The maternal germline-derived differential methylation region (DMR), which is the putative imprinting control region for this gene, was replaced by a loxP-flanked "neo:URA:tACE-Cre" cassette containing a neomycin resistance gene, a yeast orotidine-5' phosphate decarboxylase gene, and the Cre recombinase coding sequence under control of the testis-specific promoter of the angiotensin-converting enzyme gene. The cassette was excised by Cre recombinase upon passage through the male germline, leaving a single loxP site in place of the DMR. (J:82809)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
