The targeting construct replaced the Igh Smu sequence with a loxP site, the human IGH mu constant sequence, a loxP site flanked neomycin resistance gene cassette, and the human epsilon constant sequence. Cre-mediated recombination is required to achieve expression of the Cepsilon sequence. (J:222037)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count