This allele from project Rab6b-7421J-M4508 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GTAAGACCAGCCTATGGCTA, CTAGCCATAGGCTGGTCTTA, GCTCTCCAGACAGGGTCCAC, and AGGGAGCATTGAGCTCAGAG, which resulted in a 178 bp deletion spanning exon 2 beginning at Chromosome 9 positive strand position 103,140,328bp, CCTAGCCATAGGCTGGTCTT and ending after CTCTGTCTCTGCCTGTGGAC at 103,140,505 bp (GRCm38/mm10). This mutation deletes exon 2 and 119 bp of flanking intronic sequence including the splice acceptor and donor. This mutation is predicted to result in an amino acid sequence change after residue 23 and early truncation 5 amino acids later. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
Intragenic deletion
Not Specified
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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