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A construct consisting of an FRT site, splice acceptor site, IRES, LacZ gene, loxP site neo cassette, FRT site and loxP site was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exons 2 and 3. LacZ expression was detected in the organ of Corti. qRT-PCR analysis confirmed the absence of mRNA expression in homozygous mutant mice. (J:221594)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
