A targeting vector was designed to have a loxP site upstream, and a FRT-flanked neo cassette with 3' loxP site downstream of the entire coding region (~4000 bp) of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:240070)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count