The targeting construct introduced into the locus a CAG promoter, floxed stop cassette and the human sequence lacking its pro-domain (p20p10Casp6). Following cre-mediated recombination, a self-activating form of the protein of produced. (J:229300)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count