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A 11-kb genomic DNA fragment containing the entire H2-Abp gene, including 2.4 kb of 5'- and 3.5 kb of 3'-flanking sequence, was modified by replacement of the second exon with that of the H2-Abq allele, which differs from Abp at codons 85, 86, 88, and 89. An additional 1.1 kb of 5' flanking sequence from the H2-Ab1b gene was inserted upstream of the H2-Abp/Abq fusion gene to ensure the inclusion of all regulatory elements necessary for normal MHC class II expression. (J:19734)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
