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A loxP site, a copy of the human AU/U rich elements of the human FOS gene, mouse Edn1 3' UTR, two copies of transcriptional insulators from the chicken ACTB gene, neo cassette, loxP site and Adm2 3' UTR were inserted just downstream of the stop codon via homologous recombination. In the absence of cre expression, the presence of the AU/U rich element destabilizes the mRNA, reducing expression. Following cre mediated recombination the Adm2 3' UTR stabilizes the mRNA, increasing expression. (J:220962)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
