Log In|Sign Up
EN
Exon 41 was replaced with a modified exon 41 with nucleotide substitutions (GGG to AGC) that results in the substitution of serine for glycine at position 2019 (G2019S). A floxed neomycin cassette was placed immediately downstream of exon 41 and was removed via cre-mediated recombination. Kinase activity is increased about 1.8-fold in heterozygotes and about 4-fold in homozygotes. (J:223350)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
