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CRISPR mutagenesis induced a 1 nt insertion. This introduces a frameshift mutation into the codon for amino acid 14, leading to an abolition of the hydrophobic structure that normally forms the 1st transmembrane segment of the protein. A premature stop codon is generated after amino acid 68 in the open reading frame. (J:90559, J:256020)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
