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The transgene expresses a novel tetracycline transactivator (tT) protein variant with a 13-amino acid SV40 nuclear localization signal (nls), optimized codons and, in place of the strong Herpes simplex VP16 activation domain, three ~14-amino acid minimal activation domains under the control of a forebrain-specific promoter fragment, comprising 8.5 kb of 5' flanking sequence and 84 base pairs of the first, noncoding exon, of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) gene. This is one of four transgenic mouse lines with the SV40 nls that were generated. (J:129344)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
