The targeting vector was designed to insert a loxP site upstream of exon 2, a loxP site downstream of exon 2, followed by an FRT-flanked neomycin resistance (neo) cassette, and a third loxP site. Exon 2 is the first coding exon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:228786)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count