Abcb10^tm1.2Tafu

Cre-mediated recombination removed the loxP flanked exon 3, causing a frameshift mutation at the splice junction site across exons 2 and 4. This results in disruption of 3 transmembrane motifs and an ATP-binding domain that is encoded by the downstream region of exon 3. Western blot analysis confirmed absence of protein in homozygotes. (J:223428)