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A construct containing an unmutated version of VDJH2 from the 8D10 hybridoma (VGAM3.8 family VGK7 germline gene rearranged to D and JH2) with a TGT to TGC mutation at codon 92 to remove a cryptic heptamer site was inserted in the JH4 intron. To create the "unmutated" VDHJ2 a 123 bp region containing the mutated Vh region was replaced with the corresponding piece from a VGK7 germline gene. A floxed neo selection cassette was removed by cre mediated recombination. (J:218675)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
