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A GAC to GCT codon change was inserted in exon 7 and an FRT flanked neo cassette was inserted in intron 6 via homologous recombination. The condon change results in an Asp274Ala substitution. Flp mediated recombination removed the neo cassette. Immunoblot analysis detected the presence of the 58 kDa form but not the cleaved 50kDa form in liver lysates from homozygous mice. The mutant protein lacks protein phosphatase activity. (J:218791)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
