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A loxP site was inserted upstream of exon 3' and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted downstream of exon 3'. The neo cassette was removed through subsequent flp-mediated recombination. The floxed exon 3' was deleted through cre-mediated recombination. This deletion specifically knocks out the specific deltaN isoform that uses an alternative exon 3 that lacks the acidic transactivation domain sequence. (J:218385)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
