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An FRT flanked selection cassette was inserted in intron 2 and the codon in exon 3 for Cys61 5'-TGT-3' was mutated to 5-GCT-3' encoding alanine via homologous recombination. Flp mediated recombination removed the selection cassette. The mutation in exon 3 disrupts the isopeptidase activity of the protein. However regulatory properties of the protein are intact. (J:217664)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
