Tg(hs692-cre/ERT2,-GFP)103Jlr

This transgene contains the human enhancer element hs692, which is flanked on human Chr 11 by the inscuteable homolog (Drosophila) (INSC) and SRY-box 6 (SOX6) genes, followed by a minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:94077)