The targeted vector inserted a loxP site and FRT-flanked splice acceptor, IRES sequence and beta-geo cassette upstream of exon 4 and inserted a second loxP site downstream of exon 6. Flp-mediated recombination removed the beta-geo cassette. (J:223124)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count