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A targeting vector was designed to remove the 3' region of exon 2 and a 600 bp intronic sequence common to all isoforms and replace it with a neomycin-resistance cassette and an in-frame stop codon after the last codon of the remaining exon 2. qPCR analysis of hippocampal and cortical mRNA from 50 day old heterozygous females indicates an approximate 50% reduction of mRNA and Western blot confirmed an approximate 50% reduction in protein. (J:222555)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
