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The Syrian hamster prion protein promoter drives the expression of the longest form of the human four-repeat tau with the R406W mutation. Lines 21807, 21783, and 21768 were established. RT-PCR confirmed expression of mRNA in the brain and Western blot analysis shows that expression level is about 80% that of the endogenous mouse levels. (J:95971)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
