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A NLS-lacZ-polyA cassette was inserted into intron 19. It was flanked on the 5'end with a single FRT site and on the 3' end with a single loxP site. An additional loxP site followed by another FRT site was inserted into intron 23. Flp-mediated recombination in ES cells deleted the expression cassette and exons 20-23 (i.e. the kinase domain encoding exons). Western blot confirmed that no detectable protein is expressed from this allele. (J:226955)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
