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A 12 kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the cysteine residue at position 111 was replaced by serine. Five lines were established, including lines N, P, and Q. This line has 39-48 copy numbers of the transgene (J:221350)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
