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Exon 12, encoding the zinc finger domain, and 55bp of flanking sequence from intron 11 and 106bp of flanking sequence from the 3-prime UTR from the CAST/EiJ sequence of Prdm9 was inserted in place of that of the endogenous sequence in B6(Cg)-Tyr/J derived ES Cells and an FRT flanked neomycin selection cassette was inserted 621bp downstream of the end of exon 12. Breeding to a Cre deleter strain excised the neo cassette. (J:226896)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
