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The exon 1 coding sequence was flanked by two loxP sequences inserted in the 5' untranslated region of exon 1 and in intron 1. A FRT-flanked neomycin selection cassette located 3' to the loxP site in intron 1 was deleted via Flp-mediated recombination. Cre-mediated recombination removed the loxP flanked exon 1. RT-PCR, Western blot and immunohistochemical analyses revealed no detectable transcripts or proteins in thoracic tissues (e.g. lung and aorta) from homozygous mutant mice. (J:214736)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
