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The transgene was designed with the murine insulin I (Ins1) promoter driving expression of an H2B-mCherry fusion protein (coding sequence for the human HIST1H2BB gene [histone 1 H2bb] with a C-terminal monomeric red fluorescent protein sequence). The founder was determined to transmit the transgene to approximately 75% of F1 offspring, indicative of 2 independent transgene insertion sites. One of these sites was subsequently determined to be silent and was bred out. Nuclear-localized mCherry fluorescence is observed in all pancreatic beta cells. Fluorescence is not seen in any other cells. (J:214617)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
