An eGFP-expression construct was inserted behind the ATG start codon in the first exon. A loxP-flanked neomycin selection cassette was inserted into intron 1. The neomycin cassette was removed via Cre-mediated recombination. This allele expresses a eGFP-Tref1 fusion protein with colocalizes with endogenous gene product at telomeres. (J:225055)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count