A loxP site was inserted in intron 1, and an FRT-flanked neomycin selection cassette followed by a second loxP site was inserted into intron 4. Exons 2-4 were deleted in ES cells via cre-mediated recombination. (J:224769)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count