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Two loxP sites were inserted sequentially into the gene separated by 65 kb of genomic sequence, flanking exons 2 to 21. The 5 and 3 neomycin resistance gene cassettes were removed by transfection of the correctly targeted ES cells with a Cre- or Flp-recombinase encoding expression plasmid, respectively. The final targeted loxP-flanked allele contains a loxP site in the first intron and a FRT/loxP site downstream in the 21st intron of the gene. (J:226676)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
