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Human BBS4 and a localization and purification (LAP) tag (GFP followed by a cleavage site for Tobacco Etch Virus (TEV) protease and an S-tag) were placed under the control of the beta actin (Actb) promoter in a transgenic vector. Expression of the transgene is highest in testis, followed by brain, adipose, eye, heart and very slight expression is seen in trachea, lungs and bone. No expression is observed in the liver or skin. Immunofluorescence assays confirm that localization of transgene expression is similar to endogenous BBS4, such that it localizes to the centrosome and cilia. (J:199518)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
