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The mouse Nlrc4 cDNA with a mutation equivalent to the human A to C transversion at position 1589 in exon 4 (changing a histidine to a proline at position 443) and three HA tags is under the control of an invariant chain promoter. Three lines were created: 1, 2, and 3. Line one shows an approximate 3.1-fold increase in Nlrc4 levels in the spleen compared to endogenous levels. (J:219652)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
