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The transgenic construct was made using C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-352G18 containing the entire sirtuin 6 locus (Sirt6) as well as 109 kbp of centromeric flanking sequences (including a portion of the Gna15 locus, several complete loci [Gna11, Aes, Tle2, Tle6, BC025920, Ankrd24] and predicted genes [Gm31878, Gm31936, Gm32024]) and 70 kbp of telomeric flanking sequences (including the predicted gene Gm10778). The RP23-352G18 BAC DNA was modified only by insertion of an ampicillin resistance cassette. Founder line 1 has a 2-4 fold greater expression of Sirt6 as compared to wild-type. (J:229077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
